RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
HOTAIR
RNA ID
RNA Type
mRNA
Alteration Pattern
dna methylation
Species
homo sapiens
Detection Methods
RT-PCR; dual-lucimmunofluorescenceerase reporter assay etc.
Target
PTEN
Pathway
ERK; PI3K-AKT SIGNALING PATHWAY
PubMed ID
Title
HOTAIR Epigenetically Modulates PTEN Expression via MicroRNA-29b: A Novel Mechanism in Regulation of Liver Fibrosis
Year
2017
Function
A histone deacetylase-4-dependent mechanism underlies the epigenetic silencing of mmp genes during tissue fibrogenesis.
RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
HOTAIR
RNA ID
RNA Type
lncrna
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
qRT-PCR; etc.
Target
HOTAIR
Pathway
NA
PubMed ID
Title
HOTAIR Epigenetically Modulates PTEN Expression via MicroRNA-29b: A Novel Mechanism in Regulation of Liver Fibrosis
Year
2017
Function
"We demonstrate that hotair downregulates mir-29b expression and attenuates its control on epigenetic regulation, leading to enhanced pten methylation, which contributes to the progression of liver fibrosis."